Antiretroviral therapy
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ShareOnce antiretroviral therapy (ART) is initiated, patients generally remain on medications indefinitely. A change in the ART regimen is often necessary because of both acute and chronic toxicities, concomitant clinical conditions, and development of virologic failure. The approach to patients who need to change
ART will differ depending on several issues, including the reason for change, the amount of previous ART experience, and the available treatment options. For example, when patients develop an adverse effect to a drug during their first ART regimen,
ysl canada, effective treatment may be easily accomplished by substituting another agent for the offending drug in the regimen.
If only one drug was taken, HIV would quickly become resistant to it and the drug would stop working. Taking two or more antiretrovirals at the same time vastly reduces the rate at which resistance would develop, making treatment more effective in the long term.
Antiretroviral therapy are medications for the treatment of infection by retroviruses, primarily HIV. When several such drugs, typically three or four, are taken in combination, the approach is known as highly active antiretroviral therapy
Standard antiretroviral therapy (ART) consists of the use of at least three antiretroviral (ARV) drugs to maximally suppress the HIV virus and stop the progression of HIV disease. Huge reductions have been seen in rates of death and suffering when use is made of a potent ARV regimen.
The National Institutes of Health and other organizations recommend offering antiretroviral treatment to all patients with AIDS. Because of the complexity of selecting and following a regimen, the severity of the side effects and the importance of compliance to prevent viral resistance,
doudoune montreal, however, such organizations emphasize the importance of involving patients in therapy choices and recommend analyzing the risks and the potential benefits to patients without symptoms
Clinicians should discuss the risks and benefits of initiating ARV therapy with asymptomatic patients with two successive measurements of viral load >100,
columbia jackets canada,000 copies/mL and CD4 count >350 cells/mm3. This discussion should include the increased risk of transmitting HIV in the setting of higher viral load
In order to understand how ARV's work we need to know about the lifecycle of the HI Virus. HIV infects cells of the immune system and turns the cells into virus factories: one virus can create millions more of itself,
christian louboutin bottes, using our own cells for this purpose.The cells that HIV targets are called CD4 cells, which form an important part of the immune system. Once HIV enters these cells it goes through several steps before new HI viruses are produced. Each type of ARV works at a different step of the HIV lifecycle. You medical doctor or health care worker can explain to you in more detail how this works.
Immune reconstitution illness occurs most often in patients with advanced immunodeficiency, when the recovery of immune function causes new immunologic and/or inflammatory responses to an existing OI (eg, disseminated Mycobacterium avium complex, cytomegalovirus, and others) causing new symptoms such as high fever, painful lymph node enlargement, or local inflammatory syndromes. Clinical presentations can be atypical compared to the same OI in patients with untreated HIV infection, and most cases improve without discontinuing ART.
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